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Pain due to a condition called complex regional pain syndrome. Research suggests that applying DMSO 50% cream to the skin improves pain in people with complex regional pain syndrome.Skin and tissue damage caused by chemotherapy when it leaks from the IV. Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein into the skin or surrounding tissue. Research suggests that applying DMSO to the skin might prevent further damage in the event that this happens.Shingles (herpes zoster). Research suggests that applying DMSO to the skin along with a drug called idoxuridine reduces lesions and swelling associated with shingles.Inflammatory bladder disease. Research suggests that washing the bladder with DMSO improves symptoms in people with long-standing inflammatory bladder disease.Pain caused by shingles. Research suggests that applying DMSO to the skin along with a drug called idoxuridine reduces pain caused by shingles. This condition is known as post-herpetic neuralgia.
A condition called amyloidosis. Some early research suggests that applying DMSO to the skin, taking DMSO by mouth, or washing the bladder with DMSO might help treat amyloidosis.Bile duct stones. Early research suggests that DMSO might help dissolve bile duct stones when infused into the bile duct with certain other solutions.Cancer-related pain. Early research suggests that injecting DMSO intravenously (by IV) along with sodium bicarbonate might improve quality of life in people with cancer-related pain.Foot ulcers associated with diabetes. Early research suggests that applying DMSO to the affected skin might improve the healing of foot ulcers in people with diabetes.High blood pressure in the brain. Some evidence suggests that DMSO might lower high blood pressure inside the brain when injected intravenously (by IV).Arthritis. Early research suggests that applying DMSO to the skin might help decrease symptoms of osteoarthritis or rheumatoid arthritis (RA).Stomach ulcers. Early research suggests that taking DMSO might be more effective than the drug cimetidine for treating ulcers in people with ulcers caused by bacteria called Helicobacter pylori or those with ulcers that haven't healed with other medications.Pressure ulcers. Early research suggests that applying DMSO 5% cream to the skin along with massage does not help prevent pressure ulcers in people living in nursing homes.Helping skin heal after surgery. Early research suggests that applying DMSO to the skin might help the skin heal after surgery.Tendon injuries (tendinopathy). Early research suggests that applying DMSO 10% gel to the skin might improve pain and joint movement in people with tendon injuries.Headaches.Eye problems.Gall stones.Muscle problems.Asthma.Skin problems such as calluses.Other conditions.More evidence is needed to rate the effectiveness of DMSO for these uses.
Zuurmond, W. W., Langendijk, P. N., Bezemer, P. D., Brink, H. E., de Lange, J. J., and van loenen, A. C. Treatment of acute reflex sympathetic dystrophy with DMSO 50% in a fatty cream. Acta Anaesthesiol.Scand. 1996;40(3):364-367. View abstract.
Acute Reflex Sympathetic Dystrophy (acute RSD) was defined using a reproducible classification. Elevated temperature of the affected extremity ("calor"), measured by the dorsal side of the observer's hand and mentioned by the patient, pain ("dolor") measured by the Visual Analogue Scale (VAS), redness ("rubor"), edema ("tumor") and limited active range of motion ("functio laesa"), all contributed to the classification system. Patients scoring 4 to 5 positive symptoms were considered to have acute RSD. A prospective, randomized and double blind study was performed in 32 patients, all suffering from acute RSD. In all of these patients the primary injury was the result of a previous accident. One patient was taken out of the study because of his surgery. The study involved treatment with a fatty cream with 50% dimethyl sulfoxide (DMSO, group A), or without DMSO (placebo, group B), both for 2 months. All patients received physiotherapy applied within pain limits. Application of the creams resulted in both groups in an improvement of RSD-scores and VAS-scores after 2 months. However, the improvement of the RSD score in patients of group A (DMSO-group) was significantly (P < 0.01) better compared to group B. The results suggest a certain activity of DMSO 50% cream in patients suffering from RSD and is, therefore, recommendable.
Background: Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction. Topical combinations of α2-adrenergic receptor agonists or nitric oxide donors with phosphodiesterase or phosphatidic acid inhibitors formulated to treat microvascular dysfunction have been shown to reduce allodynia in a rat model of CRPS-I. Driven by these findings, we assessed the outcomes of CRPS patients treated with a compound analgesic cream (CAC) consisting of ketamine 10%, pentoxifylline 6%, clonidine 0.2%, and dimethyl sulfoxide 6% to 10%.
Oh, and it is not a performance enhancing drug. it is more like some asprin cream except it has anti-inflamatory properties. More like a liquid Ibuprofen, but concetrated. It isnt like you can slather on some DMSO and go run the Boston Marathon or make the olympic team.
We conducted a review of all 15 patients treated with DMSO for NAC congestion at our institution between May 2019 and October 2020. DMSO was applied in liquid form on a soaked gauze pad in the hospital; patients were instructed to apply a DMSO cream to the NAC twice a day following discharge. Patient characteristics and data related to DMSO treatment and NAC healing were compared via univariate analysis.
Related to its ability to dissolve many salts, DMSO is a common ligand in coordination chemistry.[11] Illustrative is the complex dichlorotetrakis(dimethyl sulfoxide)ruthenium(II) (RuCl2(dmso)4). In this complex, three DMSO ligands are bonded to ruthenium through sulfur. The fourth DMSO is bonded through oxygen. In general, the oxygen-bonded mode is more common.
DMSO is connected to the death of Gloria Ramirez, also known as "the Toxic Lady". On the 19th of February 1994, Ramirez presented to an ER with severe heart palpitations, and while treating her, several members of staff fell ill, some severely. Some staff members required extended stays in hospital, and Ramirez herself died in hospital.[48] Ramirez is known to have used a DMSO cream for management of her cancer pain, which built up in her blood due to kidney failure.[49] One lab investigating the death and illnesses posited that the high levels of DMSO in Ramirez's blood broke down when exposed to air into dimethyl sulfate, a highly toxic gas, causing the staff illnesses, and possibly her own death.[50]
DMSO is a chemical byproduct of paper making and is used as an industrial solvent, as well as for medicine. The Food and Drug Administration (FDA) has approved DMSO for intravesical use. That means it is instilled in the bladder by a doctor to treat interstitial cystitis. DMSO is also used in creams and taken by mouth for pain and other conditions. Unlike MSM, DMSO is absorbed through the skin.
Several case reports suggest that DMSO, applied in creams or taken by mouth, may help treat amyloidosis, a condition where protein builds up in the body's organs and damages them. However, because the condition is rare, there are no scientific studies about DMSO and amyloidosis. Take DMSO, or apply it in creams, only under your doctor's supervision.
Ointments, creams, lotions, and dusting powders containing sulfur are available to treat skin rashes. Natural sulfur baths, the kind usually found at hot springs, may help ease pain associated with arthritis.
The researchers first tested the ability of different amounts of DMSO and PVA, alone or in combination, to prevent the death of cultured cells in a dish that were exposed to a freezing temperature. They found that 2% DMSO combined with 1.6 mg/mL PVA yielded the highest cell survival (about 80%), while protecting the cell membrane and cytoskeleton. This combination, which the researchers called SynAFP, also allowed cells to divide and express proteins more normally after cold stress. Then, the team mixed SynAFP with a commercial aloe vera cream and applied it to the skin of mice 15 minutes before a cold challenge. The cream reduced frostbite wound size, tissue damage and inflammation, and sped healing, compared with no treatment. The cream did not prevent frostbite when applied 30 minutes or more before the cold challenge; however, multiple applications did not damage skin. The effects of the antifreeze cream in people, and how frequently it needs to be reapplied, must still be determined, the researchers say.
Topical application of insulin for wound healing can be traced back to the 60s and 70s.21 The use of topical insulin to heal wounds decreased after that era, but few studies have been performed until the late 90s. Recently, insulin solutions, sprays, cream, and dressings have been successfully used to treat diabetic and non-diabetic wounds.22 Furthermore, topical insulin has continuously garnered attention with the development of more advanced materials for long-term release of bioactive insulin. The importance of topical insulin in wound healing was summarized in Figure 1.Figure 1 The summary of topical insulin in wound healing. The application of topical insulin consists of local injection, insulin spray and cream, and dressing delivery system. This study includes 15 animal studies and 10 clinical studies of topical insulin for wounds. The results exhibited that topical insulin can improve wound closure, reduce wound healing time, and improve wound remodeling through modifying inflammation, accelerating epithelialization and neovascularization. No adverse systemic effects (hypoglycemia, hypokalemia, hypoaminoacidemia) and adverse local effects (infection, pain, allergenicity) were observed. 59ce067264
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