Gaw5.6T02-4-DL-R1B010-ME.EN Whole Image(0222163812) (1).en Whole Image
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As we mentioned earlier, whole image radiomics relies on various software packages, with a number of different algorithms developed for extracting a plethora of features from contrast-enhanced images that include nucleus to cytoplasm volume ratio, gray level co-occurrence matrix, and texture features to name but a few. There is no proven consensus on the ideal number of radiomic features needed for accurate prediction of cancer behavior. However, there are general trends towards a minimum of 30 features. More extensive radiomic feature extraction is likely to yield prognostic information but may not necessarily enhance prediction of tumor behavior [ 9 ].
The analysis of tumor biopsy is a well-established technique with high sensitivity and specificity [ 8, 9 ]. The most common genomic assays in oncology are based on WES or WGS (whole-exome or whole genome sequencing), which identify somatic mutation patterns in cancer cells, including mutations in the KRAS gene (c.35G>A, p.G12D) and BRAF gene (c.1799T>A, p.V600E) [ 10 ]. The analysis of tumor biopsy also produces a map of the gene expression profile of the tumor, providing insight into the normal and tumor-specific expression patterns of thousands of genes. This data can be studied to gain insight into tumor-specific biological processes such as therapeutic response and metastasis. Consequently, these biological insights combined with the genetic information can be used to improve cancer diagnosis, prognostication, and treatment response prediction, among other applications [ 11 ]. (Literature search methodology in Appendix 1 and Supplemental Fig. 1 ). 3d9ccd7d82
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